Excitement among patients and researchers as custom-built jabs enter phase 3 trial

Doctors have begun trialling in hundreds of patients the worldas first personalised mRNA cancer vaccine for melanoma, as experts hailed its agamechanginga potential to permanently cure cancer.

Melanoma affects about 132,000 people a year globally and is the biggest skin cancer killer. Currently, surgery is the main treatment although radiotherapy, medicines and chemotherapy are also sometimes used.

Gideon Falter was in running to be adviser but governmentas antisemitism tsar warned against appointment

• Who are CAA, the group headed by campaigner in Met police antisemitism row?

The Home Office considered appointing campaigner against antisemitism Gideon Falter as an adviser to its counter extremism unit but was warned against the appointment by the governmentas antisemitism tsar.

The Guardian understands there were strong objections to Falter being offered the part-time civil service role advising the Commission for Countering Extremism (CCE) in 2022 and that John Mann told the then home secretary Suella Braverman he would quit if Falter was offered the post.

Former coalition partnersa decision brings Scottish first minister to brink of losing vote, which could make his position untenable

• Explainer: what was the SNP and Greensa deal?

Humza Yousaf could be forced to quit as Scotlandas first minister after the Scottish Greens announced they would back a motion of no confidence against him at Holyrood.

The Scottish National partyas former coalition partners declared they would vote next week against the man who had abetrayeda them, hours after he unilaterally ended their power-sharing deal.

Stark new projections suggest annual admissions will rise to 151,000, costing the NHS and economy APS75bn

The number of people in the UK experiencing a stroke will increase more than 50% to 151,000 a year by 2035, costing the NHS and the economy APS75bn in healthcare and lost productivity, stark new projections suggest.

Worsening physical health, rising alcohol consumption and low exercise levels among an ageing population as well as a failure by ministers and the health service to do more to prevent ill health are blamed for the predicted spike in strokes.

Wang Yi says recent improvements in ties face adisruptionsa amid threats of sanctions over support for Russiaas defence industry

Chinaas foreign minister, Wang Yi, has warned the US that the recent improvements in the two countriesa relations were being jeopardised by adisruptionsa which could take them back to a adownward spirala leading to rivalry, confrontation and even conflict.

Wang was speaking at the start of a meeting in Beijing with the US secretary of state, Antony Blinken, at a time of renewed tension in the relations between the superpowers.

First payments to be made during an ongoing conflict is aimportant step towards restoring justicea, says first lady, Olena Zelenska

The first reparation payments are to be made in the next few weeks to survivors of wartime rape by Russian soldiers during the invasion of Ukraine, in a move that Ukraineas first lady, Olena Zelenska, called aan important step towards restoring justicea.

Up to 500 Ukrainian survivors of conflict-related sexual violence are being identified and awarded with interim reparations this year, including financial, medical and psychological support.

Exclusive: Action by organisation supporting migrants argues new rules are discriminatory

An organisation that supports migrant workers has launched a legal challenge against the governmentas new policy to bar care workers from bringing children and partners to the UK, warning that it is atearing families aparta.

According to Migrants at Work, care workers have to choose between family life with their children and partners or getting a job as a health or social carer in the UK a they can no longer do both.

Teachers say behaviour getting worse as survey also shows parents getting less supportive of school policies

Only two in five children in England say they always feel safe at school, according to a government survey, and teachers from across Britain have told the Guardian they have seen pupilsa behaviour deteriorate over the last two years.

Teachers said violence and abuse aimed at school staff and other students had increased alongside displays of homophobia, racism and sexism, with women in particular bearing the brunt of aggressive sexual remarks.

Concern grows over legality of governmentas approach as new figures show more than 150,000 carers facing huge penalties

• A hero a then sacked. The careras allowance whistleblower

New figures show more than 150,000 unpaid carers are now facing huge fines for minor rule breaches, as MPs, charities and campaigners demanded an immediate amnesty.

Ed Davey, the Lib Dem leader, joined calls to write off the vast debts incurred by tens of thousands of people who care for sick, disabled and elderly relatives after experts raised concerns about the legality of the governmentas approach.

Arrests as Chinese authorities working with UK police and international trademark agencies seize millions of parcels bound for customers worldwide

Chinese authorities have targeted a major online sales platform accused of supplying counterfeit goods, raiding warehouses holding millions of packages destined for overseas buyers.

Earlier this month police raided the Hangzhou office and several warehouses of Pandabuy after reported legal action by 16 brands over copyright infringement. More than 200 public security branch officers, 50 private sector investigators and local police were involved, according to reports.

Campaign Against Antisemitism, led by Gideon Falter, was set up by activists who felt existing groups were not doing enough

• Home Office considered antisemitism campaigner for counter-extremism unit

The group, which is led by Gideon Falter, was founded in response to the 2014 Israel-Gaza offensive, by a group of activists concerned about rising antisemitism and who believed some Jewish communal organisations such as the Board of Deputies were not doing enough to robustly combat antisemitism at protests and in the media.

Those vying for job say it will put region on more equal footing with areas such as West Midlands and Greater Manchester

The Conservatives are anot taking accountabilitya for their part in leaving regions such as the east Midlands to suffer with poor infrastructure, growing inequalities and a skills gap, Labouras candidate for the regionas first mayor said.

Claire Ward, the former MP for Watford, said there was not enough to keep young people in the east Midlands and that people had alost hopea.

Aspirations for statehood revived among younger generations in refugee camps where war has consumed daily life

The red inverted triangle is everywhere a stencilled on walls, sprayed on store shutters, a constant theme guiding visitors through the narrow alleyways that dissect the Burj al-Barajneh refugee camp in Beirut.

Appearing initially in combat videos released by Hamas in which its fighters target Israeli tanks in Gaza, the newfound ubiquity of the logo in the camp 170 miles (270km) away signals a shift in opinion in favour of armed struggle.

The actoras feminist credentials, a wholehearted embrace of comedy and being one of the most memed actors on social media has seen Goslingas auto-satirising alpha male become white-hot box office in 2024

In Hollywood, there are no accidents. Ryan Goslingas role in stuntman pic The Fall Guy, hard on the heels of his show-stopping Oscars rendition of Iam Just Ken, is perfectly timed to confirm his ascension to the very top tier of stardom. Not only is it a four-quadrant entertainment turbo boost a covering all audience bases with action, romance, a legacy franchise for the oldies, John Wick-slick for the kids a it is shrink-wrapped to his public persona. His role as stunt veteran Colt Seavers, saving the skin of the idiot megastar he doubles for, caps off the stance Gosling has upheld on talkshows and memes over the last decade: stardom and celebrity as a delectable facade, an in-joke between star and audience to be played with the lightest of ironic touches.

But of course Gosling is a bona fide star, one of Hollywoodas most important. His confused, toxic himbo Ken stole the Barbie limelight from Margot Robbie. Tunnelling into classic archetypes of masculinity with modern self-awareness is the on-screen niche he has made his own a giving us a new, uniquely supple male star for the post-#MeToo era. His mainstream roles a getaway drivers, daredevil motorcyclists, venal bankers a have often been ultra-macho, but the actor himself comes with rounded metrosexual edges. Men want to be him, with his debonair cool and inexhaustible supply of swanky jackets (the leather Miami Vice stunt-team number in The Fall Guy being the latest). As far back as 2017, Morwenna Ferrier noted that Gosling clones, sporting a certain aturbo cleanlinessa, were now on the loose in cities everywhere.

Muslims worry Modias party will rely on familiar tactics of drawing on religious divisions as it battles Congress to to retain seats in Karnataka

The sun scorched the carpeted car park at Mudipu Junction outside Mangalore in Karnataka state as volunteers arranged rows of red plastic chairs and placed mounds of biryani and fruit on the table for a public iftar, the moment Muslims break their fast during Ramadan.

But this was no ordinary iftar. India is in the midst of a general election during which prime minister Narendra Modi and his Hindu nationalist Bharatiya Janata Party (BJP) are seeking a third term, and factionalism is rife.

From a modern development in the heart of Edinburgh to a Grade II-listed townhouse in Ramsgate

The sweeping foreign aid package passed by congress has drawn the ire of China, but billions of dollars will actually stay in the US

Taiwanas president Tsai Ing-wen has praised the US Congress for passing a sweeping foreign aid package this week which included arms support for the island, and has drawn the ire of China.

After months of delays and contentious debate, the bill was signed into law by Joe Biden on Wednesday. Described as $95bn in aid for Ukraine, Israel and Taiwan, the legislation actually contains provisions that broadly affect many parts of the Asia-Pacific, while also spending billions of dollars at home in America.

Now living in comparative freedom in Iran, 26-year-old Mahtab Eftekhar describes facing motherhood at 12 and explains why seeking justice for other women means she no longer fears death

At the age of 10, while still in the third grade, I received news from my mother and stepfather that we would travel to Helmand province for my brotheras wedding. Little did I know, it was to be my own wedding, as my family had arranged my marriage to my cousin and sold me for 40,000 Afghanis [APS500], without my knowledge or consent.

That night, after the wedding, I went to sleep beside my mother and little brother, only to wake up next to my cousin. Trembling from confusion and fear, I fled the room in tears and screams. But my mother and her sister coerced me back into that room. It was then that I was told I had been married to my cousin.

This omission demonstrates a troubling facility with concealment, writes advice columnist Eleanor Gordon-Smith. To move forward, you need to be satisfied there are no more big surprises

After several months of dating, my partner revealed he had another ex-wife and three teenage children. Head only ever mentioned one ex-wife and two small children. He explained his rationale and I decided to continue with the relationship. I had been single for 15 years and I feel Iave really connected with him.

We have the best time together, and although heas away a lot with work, heas communicative, considerate and has given me the sort of relationship I never thought Iad find. I feel he genuinely loves me and wants the best for me. Heas always saying how much he appreciates me. But I am nervous about the future as he has so many commitments (I donat have children but hope to one day, and heas on board).

Budget ice baths, graveyard sleepovers and a night of slam poetry in Norwich! Joe Wilkinson and Katherine Ryan are super fun as they hunt for adventures that donat break the bank

Channel 4 has carved out a particular niche in daytime-shaped TV shows airing at night. This largely means that an afternoon-ish format, of the sort that would usually be broken up with ads for life insurance, animal charities and conservatories, now comes with the added frisson of knowing that a well-known comedian might say a bad word a see, for example, Eight Out of 10 Cats Does Countdown. Here we are, then, in familiar territory, with Joe and Katherineas Bargain Holidays, a strangely late-afternoon-meets-late-night travelogue from comedians Joe Wilkinson and Katherine Ryan, about how to enjoy a holiday on the cheap.

It was filmed in the summer of 2022 a that must be why England looks so green and pleasant, rather than soaked to the skin with six monthsa worth of relentless rain a and bears the hallmarks of peak inflation, as it searches for the best means of getting away without breaking the bank. Wilkinson is the bargain-hunter here, while Ryan leans into her luxury-loving persona. Throughout her career, Ryan has always been refreshingly open about money, and here she continues to be frank, as she shrugs off any notion of embarrassment about splashing out on nice stuff. Sheall spend APS500 on a spa day, she says, and APS300 on dinner, or more, if she gets the train from London to Paris and back, just for a romantic meal with her husband. aI just donat want to compromise on my lifestyle,a she says. aShall we compromise for a bit?a asks Wilkinson. aNo,a she replies.

A anon-hierarchicala university space that can be continually altered or even moved has won the EUas biennial prize for contemporary architecture

A lightweight university study centre designed to be easily disassembled has won the prize for the best building in Europe. Longevity, permanence and a sense of immutability might be the ambition of most architects, but Gustav DA1/4sing and Max Hacke would be delighted to see their building adapted and reconfigured, or ultimately dismantled and moved somewhere else altogether.

aWe imagined the project as a changeable system,a says DA1/4sing, co-designer of the new study pavilion for the Technical University of Braunschweig, Germany, which has been named this yearas winner of the EU Mies award (formerly the Mies van der Rohe award), the biennial European Union prize for contemporary architecture. aWe wanted it to be a counter model to the universityas high-rise building and its conventional one-sided lecture halls. Itas more like an extension of the landscape that can be forever modified, a non-hierarchical space that the students can make their own.a

Instead of buy-one-get-one-free offers, everyday life now involves carefully comparing prices and feeling increasingly powerless

Under capitalism, prices are supposed to be the centre of everything. They are the key agreement between buyer and seller. They are the one clear and reliable piece of information, on which the whole often opaque and unstable system depends.

So it struck me as strange when some of my local London shops stopped displaying the prices of some goods a couple of years ago. It started with upmarket fishmongers, and I wondered whether this was because wealthy customers didnat need to count their pennies. But then the practice spread to corner shops and greengrocers, with a wider clientele, and to everyday purchases such as fruit and vegetables. There was a cost of living crisis going on, the worst in Britain for 40 years, but parts of Hackney seemed to be in denial.

Andy Beckett is a Guardian columnist

The overcrowded city is leading the way with a tax on day trippers. Surely other great European destinations should follow suit

Venice has had enough. It is sinking beneath the twin assaults of tourism and the sea and believes the answer lies in fending off visitors by charging them to enter. It is not alone. Tourism is under attack. Seville is charging for entry to the central Plaza de EspaA+-a. In Paris, the Mona Lisa is so besieged by flashing phones she is about to be banished to a basement. Barcelona graffiti shout, aTourists go home, refugees welcome.a Amsterdam wants no more coach parties, nor does Rome.

The Venice payment will be complicated. It will apply at specific entry points only to day trippers to the city centre, not hotel guests. It will be a mere five euros and confined to peak times of day over the summer. This will hardly cover the cost of running it. It is a political gesture that is unlikely to stem the tourist flow round the Rialto and St Markas Square, let alone leave more room for Venetians to enjoy their city undisturbed by mobs.

Simon Jenkins is a Guardian columnist

Do you have an opinion on the issues raised in this article? If you would like to submit a response of up to 300 words by email to be considered for publication in our letters section, please click here.

Oral arguments over former presidentas claim of immunity seem to have left Trump happier than the justice department

aWell,a said one reporter to another as they left the supreme court chamber, sometime after noon on Thursday. aLooks like weare getting a king.a

Notwithstanding a certain mordant hyperbole on a momentous day in American history, the sentiment seemed within bounds.

A military horse that bolted through central London on Wednesday is in a aserious conditiona in an equine hospital

Sewage pollutes our waterways, species face extinction. We must act fast to halt the decline a and we will

• Steve Reed is shadow environment secretary

We must not be the last generation to have the opportunity to marvel at nature.

When I was growing up, I took for granted the excitement of climbing trees in the local woods at the end of our road, sleeping under the stars at Scout camp, and exploring the micro-worlds of seaside rockpools on holiday in Cornwall. Our children and grandchildren deserve to be astounded by the magnificence of our landscapes and coastlines, mesmerised by the beauty of a robinas song, and to splash about in the local river.

Steve Reed is the MP for Croydon North, and shadow secretary of state for environment, food and rural affairs

Only this week the first minister said he was delighted with his coalition with the Greens. But then a|

Be careful what you wish for. Itas hard not to feel a scintilla of sympathy for Humza Yousaf. On a human level, if not a political one. For well over a decade the SNP had ruled more or less unchallenged in Scotland. Free to do whatever it liked, though not, ironically, the one thing on which its existence was predicated: making Scotland independent.

The UK parliament was in no hurry to grant a second referendum, much to the SNPas displeasure. The first had been labelled a once-in-a-generation event. The SNP saw it differently. Generations pass more quickly in Scotland apparently.

Our former PM has a dire warning and a book to sell, but it isnat really cutting through. A bit more Brit-style bumbling might help

aI know the name,a texts a friend when I ask if she knows who Liz Truss is, but like most Americans canat quite put her finger on why. aLike 8%,a guesses another when I ask her to put a number on how many of her countrymen she imagines know of Truss. The standard response, in my extremely unscientific poll of Americans as to whether or not they know of Truss, however, was: aNo, should I?a a the answer to which, of course, depends entirely on whether you want to understand why the Tory party is polling around 20% or whether you happen to be Liz Truss.

Truss, the only one of us to suffer that particular misfortune, was in Washington DC this week trying, like so many minor British celebrities before her, to catch the eye of the Americans. At the Heritage Foundation, a rightwing thinktank that hosted the launch of Trussas book Ten Years to Save the West, she came bearing a awarninga. Not an ideal ice-breaker, perhaps, but one clearly tailored to an audience receptive to the frisson of the term aforces of the global lefta.

Emma Brockes is a Guardian columnist

Ali died of cancer last year. He was 21, and had to live in the choking smoke of the Rumaila oilfield

A year has passed since my beautiful boy Ali Julood died. Not a day goes by when I do not think of him smiling and playing football with his friends outside. Those days are gone. As a father, that gives me great pain.

Ali was diagnosed with leukaemia at the age of 15. The cancer caused him to drop out of school, leave his football team and spend years undergoing painful medical treatment. He died at the age of 21 on 21 April 2023.

Humza Yousafas position as first minister is in danger, but the problems predate his leadership

A year ago, Scotlandas newly elected first minister, Humza Yousaf, said that the Scottish National partyas 2021 pact with the Scottish Greens a giving him a majority in the Holyrood parliament a was aworth its weight in golda. As recently as Tuesday, Mr Yousaf was publicly buffing his treasure, insisting that he hoped the deal would continue. Less than 48 hours later, however, he decided it was time to sell, scrapping the pact and pledging instead to lead a minority SNP government for the remaining two years of this Scottish parliament. Shortly afterwards, the furious Greens vowed to back next weekas Conservative motion of no confidence against the man who had abetrayeda them.

The split is no surprise. Last week, the Scottish government scrapped its pledge of a 75% cut in carbon emissions by 2030, and its legally binding annual reduction targets. It did so after the UK Climate Change Committee declared the target ano longer crediblea because not enough groundwork had been done. The Scottish Greens reacted with anger; an emergency meeting was planned for May to decide whether to continue in government. Meanwhile, some SNP backbenchers made clear that they had had enough too. On Thursday, anxious to show decisive leadership, Mr Yousaf got in first, dumping the deal.

Do you have an opinion on the issues raised in this article? If you would like to submit a response of up to 300 words by email to be considered for publication in our letters section, please click here.